Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis.

Details

Serval ID
serval:BIB_6B85AAD6FF7E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enlarged perivascular spaces are associated with brain microangiopathy and aging in multiple sclerosis.
Journal
Multiple sclerosis
Author(s)
Borrelli S., Guisset F., Vanden Bulcke C., Stölting A., Bugli C., Lolli V., Du Pasquier R., van Pesch V., Absinta M., Pasi M., Maggi P.
ISSN
1477-0970 (Electronic)
ISSN-L
1352-4585
Publication state
Published
Issued date
07/2024
Peer-reviewed
Oui
Volume
30
Number
8
Pages
983-993
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Growing evidence links brain-MRI enlarged perivascular spaces (EPVS) and multiple sclerosis (MS), but their role remains unclear.
This study aimed to investigate the cross-sectional associations of EPVS with several neuroinflammatory and neurodegenerative features in a large multicentric-MS cohort.
In total, 207 patients underwent 3T axial-T2-weighted brain-MRI for EPVS assessment (EPVS dichotomized into high/low according to ⩾ 2/< 2 rating categories). MRI biomarkers included brain-predicted age and brain-predicted age difference (brain-PAD), central vein sign (CVS)-positive lesion percentage (CVS%), paramagnetic rim and cortical lesions, T2-lesion load, and brain volumetry. The variable relative importance for EPVS-category prediction was explored using a classification random forest approach.
High EPVS patients were older (49 vs 44 years, p = 0.003), had ⩾ 1 vascular risk factors (VRFs; p = 0.005), lower CVS% (67% vs 78%, p < 0.001), reduced brain volumes (whole brain: 0.63 vs 0.73, p = 0.01; gray matter: 0.36 vs 0.40; p = 0.002), and older brain-predicted age (58 vs 50 years, p < 0.001). No differences were found for neuroinflammatory markers. After adjusting for age and VFRs (multivariate analyses), the high EPVS category correlated with lower CVS% (odds ratio (OR) = 0.98, 95% confidence interval (CI) = 0.96-0.99; p = 0.02), lower whole brain (OR = 0.01, 95% CI = 0.0003-0.5; p = 0.02), gray matter (OR = 0.0004, 95% CI = 0.0000004-0.4; p = 0.03) volumes, and higher brain-PAD (OR = 1.05, 95% CI = 1.01-1.09; p = 0.02). Random forest identified brain-PAD as the most important predictor of high EPVS.
EPVS in MS likely reflect microangiopathic disease rather than neuroinflammation, potentially contributing to accelerated neurodegeneration.
Keywords
Humans, Male, Female, Middle Aged, Adult, Magnetic Resonance Imaging, Glymphatic System/pathology, Glymphatic System/diagnostic imaging, Multiple Sclerosis/pathology, Multiple Sclerosis/diagnostic imaging, Aging/pathology, Cross-Sectional Studies, Brain/pathology, Brain/diagnostic imaging, Enlarged perivascular spaces, brain-predicted age, cerebral small vessel disease, magnetic resonance imaging, multiple sclerosis, vascular risk factors
Pubmed
Web of science
Create date
14/06/2024 11:10
Last modification date
06/08/2024 7:02
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