Intravenous lacosamide for treatment of status epilepticus.

Details

Serval ID
serval:BIB_6B6D7EC137E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intravenous lacosamide for treatment of status epilepticus.
Journal
Acta Neurologica Scandinavica
Author(s)
Kellinghaus C., Berning S., Immisch I., Larch J., Rosenow F., Rossetti A.O., Tilz C., Trinka E.
ISSN
1600-0404 (Electronic)
ISSN-L
0001-6314
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
123
Number
2
Pages
137-141
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Objectives -  Treatment of established status epilepticus (SE) requires immediate intravenous anticonvulsant therapy. Currently used first-line drugs may cause potentially hazardous side effects. We aimed to assess the efficacy and safety of intravenous lacosamide (LCM) in SE after failure of standard treatment. Methods -  We retrospectively analyzed 39 patients (21 women, 18 men, median age 62 years) from the hospital databases of five neurological departments in Germany, Austria and Switzerland between September 2008 and January 2010 who were admitted in SE and received at least one dose of intravenous LCM. Results -  Types of SE were generalized convulsive (n = 6), complex partial (n = 17) and simple partial (n = 16). LCM was administered after failure of benzodiazepins or other standard drugs in all but one case. Median bolus dose of LCM was 400 mg (range 200-400 mg), which was administered at 40-80 mg/min in those patients where infusion rate was documented. SE stopped after LCM in 17 patients, while 22 patients needed further anticonvulsant treatment. The success rate in patients receiving LCM as first or second drug was 3/5, as third drug 11/19, and as fourth or later drug 3/15. In five subjects, SE could not be terminated at all. No serious adverse events attributed to LCM were documented. Conclusions -  Intravenous LCM may be an alternative treatment for established SE after failure of standard therapy, or when standard agents are considered unsuitable.
Pubmed
Web of science
Create date
17/01/2011 19:34
Last modification date
20/08/2019 15:25
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