Diabétologie [The DREAM of diabetes prevention]

Details

Serval ID
serval:BIB_6B64F77E953B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diabétologie [The DREAM of diabetes prevention]
Journal
Revue Médicale Suisse
Author(s)
Ruiz J.
ISSN
1660-9379
Publication state
Published
Issued date
01/2007
Volume
3
Number
94
Pages
132, 134-136
Language
french
Notes
Publication types: English Abstract ; Journal Article
Abstract
This article summarizes an important study published in 2006 in the field of the prevention of diabetes mellitus. It is the DREAM study which evaluate the therapeutic effects of rosiglitazone and ramipril versus placebo in the prevention of type 2 diabetes in high risk patients: glucose intolerance or impaired fasting glucose. In this clinical study, more than 5000 patients were followed during 3 years. The risk of diabetes was reduced with rosiglitazone of 62% (NNT 9). In the field of negative effects the risk of cardiac insufficiency was multiplied by 7 (NNH 250) but stayed a rare event (to 0,5% of the treated subjects). The ramipril had no preventive effect for the prevention of type 2 diabetes but induced a higher frequency of return towards the normoglycaemia. This treatment can be recommended for these high risk subjects.
Keywords
Antihypertensive Agents, Diabetes Mellitus, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Ramipril, Randomized Controlled Trials as Topic, Thiazolidinediones
Pubmed
Create date
03/03/2008 16:15
Last modification date
20/08/2019 15:25
Usage data