Blood pressure variability in ambulatory hypertensive patients: effect of beta-blocking agents and/or diuretics

Details

Serval ID
serval:BIB_6B5909C5180A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood pressure variability in ambulatory hypertensive patients: effect of beta-blocking agents and/or diuretics
Journal
Journal of Cardiovascular Pharmacology
Author(s)
Jacot-des-Combes  B., Brunner  H. R., Waeber  B., Porchet  M., Biollaz  J.
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
04/1984
Volume
6
Number
2
Pages
263-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar-Apr
Abstract
Using a semiautomatic device (Remler), ambulatory blood pressure was recorded in ambulatory hypertensive patients who were either untreated (n = 55) or treated chronically with beta-blocking agents (n = 28), diuretics (n = 42), or a combination of both (n = 75). In all patients, one blood pressure reading was obtained during usual activities every 30 min for 12 h. The selection of untreated patients was based on clinic measurements (two to three repeated blood pressures of greater than 140/89 mm Hg). The mean systolic and diastolic blood pressures averaged from all patients over the whole day did not differ significantly among the groups, ranging from 133.7 to 141 mm Hg for the systolic and from 83.8 to 88.4 mm Hg for the diastolic. The variability of blood pressure, reflected by the difference between the average of the three highest and the three lowest values of the day, was not different among the four groups and ranged from 41.4 to 50.6 mm Hg for the systolic and from 30.1 to 34.4 mm Hg for the diastolic. Similarly, variability expressed as the standard deviation of the mean of all blood pressures measured during the day did not differ among the groups. In all groups, blood pressure was highest in the morning and lowest in early afternoon, and tended to rise again in the late afternoon. Thus, blood pressure variability of hypertensive patients is not changed by antihypertensive therapy with beta-blocking agents and/or diuretics.
Keywords
Adrenergic beta-Antagonists/*pharmacology Adult Aged Ambulatory Care Blood Pressure/*drug effects Circadian Rhythm Diuretics/*pharmacology Female Humans Hypertension/*physiopathology Male Middle Aged
Pubmed
Web of science
Create date
25/01/2008 11:41
Last modification date
20/08/2019 15:25
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