Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis.

Details

Serval ID
serval:BIB_6B52857B61DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis.
Journal
Nature communications
Author(s)
Aguilo N., Gonzalo-Asensio J., Alvarez-Arguedas S., Marinova D., Gomez A.B., Uranga S., Spallek R., Singh M., Audran R., Spertini F., Martin C.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
14/07/2017
Peer-reviewed
Oui
Volume
8
Pages
16085
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These antigens are absent from the current tuberculosis vaccine, BCG. Here we compare the protection induced by BCG and MTBVAC in several mouse strains that naturally express different MHC haplotypes differentially recognizing ESAT6 and CFP10. MTBVAC induces improved protection in C3H mice, the only of the three tested strains reactive to both ESAT6 and CFP10. Deletion of both antigens in MTBVAC reduces its efficacy to BCG levels, supporting a link between greater efficacy and CFP10- and ESAT6-specific reactogenicity. In addition, MTBVAC (but not BCG) triggers a specific response in human vaccinees against ESAT6 and CFP10. Our results warrant further exploration of this response as potential biomarker of protection in MTBVAC clinical trials.
Keywords
Animals, Antigens, Bacterial/genetics, Antigens, Bacterial/immunology, Bacterial Proteins/genetics, Bacterial Proteins/immunology, Female, Gene Expression, Host-Pathogen Interactions/genetics, Mice, Inbred Strains, Mycobacterium tuberculosis, Tuberculosis Vaccines/immunology
Pubmed
Web of science
Open Access
Yes
Create date
11/12/2017 10:59
Last modification date
20/08/2019 14:25
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