Syndrome myasthenique de Lambert-Eaton. Aspects physiopathologiques et modalites therapeutiques. [Lambert-Eaton myasthenic syndrome. Physiopathological aspects and therapeutic modalities]

Details

Serval ID
serval:BIB_6B106C34D4C0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Syndrome myasthenique de Lambert-Eaton. Aspects physiopathologiques et modalites therapeutiques. [Lambert-Eaton myasthenic syndrome. Physiopathological aspects and therapeutic modalities]
Journal
Revue Neurologique
Author(s)
Kuntzer  T., Steck  A. J., Fiorini  E., Mirimanoff  R. O., Regli  F.
ISSN
0035-3787 (Print)
Publication state
Published
Issued date
1991
Peer-reviewed
Oui
Volume
147
Number
12
Pages
819-24
Notes
Case Reports English Abstract Journal Article Review
Abstract
A 68-year old man experienced a progressive proximal tetraparesis with anhidrosis and a single episode of horizontal diplopia before presenting exertional dyspnea; pulmonary investigations revealed a small cell carcinoma of the lung. Clinical and electrophysiological investigations with abnormal SFEMG, repetitive stimulations and autonomic assessment pointed to a pre-synaptic neuromuscular dysfunction compatible with a Lambert-Eaton syndrome. Antibodies to acetylcholine receptors and calcium channels were negative. Thoracic radiotherapy combined with chemotherapy produced marked improvement: repeated electrophysiological evaluations showed a strong correlation between median nerve CMAP amplitude and clinical course. This case prompted us to discuss current concepts of pre-synaptic dysfunction, and paraneoplastic syndrome, and to review therapeutic strategies, in the light of recent studies of Lambert-Eaton syndrome.
Keywords
Aged Carcinoma, Small Cell/complications Humans Lambert-Eaton Myasthenic Syndrome/complications/drug therapy/*physiopathology Lung Neoplasms/complications Male
Pubmed
Web of science
Create date
25/01/2008 12:43
Last modification date
20/08/2019 14:25
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