Sweet sixteen for ANLS.

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Serval ID
serval:BIB_6AF150415C7E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sweet sixteen for ANLS.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Pellerin L., Magistretti P.J.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
32
Number
7
Pages
1152-1166
Language
english
Abstract
Since its introduction 16 years ago, the astrocyte-neuron lactate shuttle (ANLS) model has profoundly modified our understanding of neuroenergetics by bringing a cellular and molecular resolution. Praised or disputed, the concept has never ceased to attract attention, leading to critical advances and unexpected insights. Here, we summarize recent experimental evidence further supporting the main tenets of the model. Thus, evidence for distinct metabolic phenotypes between neurons (mainly oxidative) and astrocytes (mainly glycolytic) have been provided by genomics and classical metabolic approaches. Moreover, it has become clear that astrocytes act as a syncytium to distribute energy substrates such as lactate to active neurones. Glycogen, the main energy reserve located in astrocytes, is used as a lactate source to sustain glutamatergic neurotransmission and synaptic plasticity. Lactate is also emerging as a neuroprotective agent as well as a key signal to regulate blood flow. Characterization of monocarboxylate transporter regulation indicates a possible involvement in synaptic plasticity and memory. Finally, several modeling studies captured the implications of such findings for many brain functions. The ANLS model now represents a useful, experimentally based framework to better understand the coupling between neuronal activity and energetics as it relates to neuronal plasticity, neurodegeneration, and functional brain imaging.
Keywords
Animals, Astrocytes/metabolism, Brain/metabolism, Energy Metabolism/physiology, Humans, Lactic Acid/metabolism, Models, Neurological, Neurons/metabolism
Pubmed
Web of science
Create date
16/12/2011 21:37
Last modification date
20/08/2019 14:25
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