Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis.

Details

Serval ID
serval:BIB_6AEAD24A0472
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis.
Journal
Frontiers in immunology
Author(s)
Geraghty D.E., Thorball C.W., Fellay J., Thomas R.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
10
Pages
970
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc-mediated antibody-function in HIV-1 immunity has led to the investigation of specific polymorphisms in FcR genes on acquisition, disease progression, and vaccine efficacy in natural history cohorts. The purpose of this review is not only to explore these known HIV-1 host genetic associations, but also to re-evaluate them in the context of genome-wide data. In the current era of effective anti-retroviral therapy, the potential impact of such variation on post-treatment cohorts cannot go unheeded and is discussed here in the light of current findings. Specific polymorphisms associating with HIV-1 pathogenesis have previously been genotyped by assays that captured only the single-nucleotide polymorphism (SNP) of interest without relative information of neighboring variants. With recent technological advances, variation within these genes can now be characterized using next-generation sequencing, allowing precise annotation of the whole chromosomal region. We herein also discuss updates in the annotation of common FcR variants that have been previously associated with HIV-1 pathogenesis.
Keywords
Fc receptors, HIV-1, disease association, next-generation sequencing, polymorphism
Pubmed
Web of science
Open Access
Yes
Create date
24/06/2019 9:01
Last modification date
20/08/2019 14:25
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