Simplified patient-specific renal dosimetry in <sup>177</sup>Lu therapy: a proof of concept.

Details

Serval ID
serval:BIB_6AE43656349F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simplified patient-specific renal dosimetry in <sup>177</sup>Lu therapy: a proof of concept.
Journal
Physica medica
Author(s)
Ligonnet T., Pistone D., Auditore L., Italiano A., Amato E., Campennì A., Schaefer N., Boughdad S., Baldari S., Gnesin S.
ISSN
1724-191X (Electronic)
ISSN-L
1120-1797
Publication state
Published
Issued date
04/12/2021
Peer-reviewed
Oui
Volume
92
Pages
75-85
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
The aim of this proof-of-concept study is to propose a simplified personalized kidney dosimetry procedure in <sup>177</sup> Lu peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors and metastatic prostate cancer. It relies on a single quantitative SPECT/CT acquisition and multiple radiometric measurements executed with a collimated external probe, properly directed on kidneys.
We conducted a phantom study involving external count-rate measurements in an abdominal phantom setup filled with activity concentrations of <sup>99m</sup> Tc, reproducing patient-relevant organ effective half-lives occurring in <sup>177</sup> Lu PRRT. GATE Monte Carlo (MC) simulations of the experiment, using <sup>99m</sup> Tc and <sup>177</sup> Lu as sources, were performed. Furthermore, we tested this method via MC on a clinical case of <sup>177</sup> Lu-DOTATATE PRRT with SPECT/CT images at three time points (2, 20 and 70 hrs), comparing a simplified kidney dosimetry, employing a single SPECT/CT and probe measurements at three time points, with the complete MC dosimetry.
The experimentally estimated kidney half-life with background subtraction applied was compatible within 3% with the expected value. The MC simulations of the phantom study, both with <sup>99m</sup> Tc and <sup>177</sup> Lu, confirmed a similar level of accuracy. Concerning the clinical case, the simplified dosimetric method led to a kidney dose estimation compatible with the complete MC dosimetry within 6%, 12% and 2%, using respectively the SPECT/CT at 2, 20 and 70 hrs.
The proposed simplified procedure provided a satisfactory accuracy and would reduce the imaging required to derive the kidney absorbed dose to a unique quantitative SPECT/CT, with consequent benefits in terms of clinic workflows and patient comfort.
Keywords
(177)Lu, Internal dosimetry, Kidney, Monte Carlo, PRRT
Pubmed
Create date
28/02/2022 12:00
Last modification date
01/03/2022 6:37
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