A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory.

Details

Serval ID
serval:BIB_6AB1AE6A30C6
Type
Article: article from journal or magazin.
Collection
Publications
Title
A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory.
Journal
Annals of Neurology
Author(s)
Mummery C.J., Patterson K., Price C.J., Ashburner J., Frackowiak R.S., Hodges J.R.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
2000
Volume
47
Number
1
Pages
36-45
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region.
Keywords
Aged, Atrophy, Dementia/pathology, Dementia/physiopathology, Female, Humans, Magnetic Resonance Imaging, Male, Memory/physiology, Middle Aged, Neuropsychological Tests, Semantics, Temporal Lobe/pathology, Temporal Lobe/physiopathology
Pubmed
Web of science
Create date
12/09/2011 20:12
Last modification date
20/08/2019 14:25
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