Ceftazidime in severe infections: a Swiss multicentre study.

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State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_6A99073857AE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ceftazidime in severe infections: a Swiss multicentre study.
Journal
The Journal of Antimicrobial Chemotherapy
Author(s)
Francioli P., Clément M., Geroulanos S., von Graevenitz A., Luthy R., Regamey C., Stalder H., Vogt M., Waldvogel F.A.
ISSN
0305-7453
Publication state
Published
Issued date
07/1983
Peer-reviewed
Oui
Volume
12 Suppl A
Pages
139-146
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Abstract
A total of 105 patients (mean age 57, range 15 to 90) with serious infections were treated with intravenous ceftazidime, usually 2 g 8-hourly. Most patients had complicating factors such as major surgery, cancer, chronic obstructive lung disease, catheters or anatomical abnormalities. Eighty-seven infectious episodes in 77 patients could be assessed for efficacy. Bacteraemia was diagnosed in 26% of these episodes. Seventy-five per cent of infections were due to Gram-negative bacteria, Pseudomonas aeruginosa being the most frequent. The major sites of infections were the lower respiratory tract (30), the urinary tract (28), the soft tissues (9), the biliary tract (4), bones (4) and the ears (4). Overall, 67% of the patients were cured, 20% improved, 7% relapsed and 6% failed to respond. Among the 27 infections due to Ps aeruginosa, only two failures (in the same patient) and four relapses were recorded. However, in the two failures and in three other cases with persistent Ps. aeruginosa colonisation, the organism had become resistant to ceftazidime. Three failures were recorded in the seven Staphylococcus aureus infections included in this study. Superinfection occurred in four patients. Adverse events included rash (6), Clostridium difficile toxin-induced diarrhoea (3), transaminase elevation (3), weakly positive Coombs test (10). Ceftazidime appears to be safe and effective for the treatment of severe Gram-negative infections, including those caused by Ps. aeruginosa.
Keywords
Adolescent, Adult, Aged, Bacterial Infections/drug therapy, Biliary Tract Diseases/drug therapy, Ceftazidime, Cephalosporins/adverse effects, Cephalosporins/therapeutic use, Clinical Trials as Topic, Diarrhea/chemically induced, Drug Eruptions/etiology, Female, Humans, Liver Function Tests, Male, Middle Aged, Osteoarthritis/drug therapy, Otitis Externa/drug therapy, Respiratory Tract Infections/drug therapy, Sepsis/drug therapy, Skin Diseases, Infectious/drug therapy, Switzerland, Thrombophlebitis/chemically induced, Urinary Tract Infections/drug therapy
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:08
Last modification date
01/10/2019 6:18
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