Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness.

Details

Serval ID
serval:BIB_6A7ED3D71396
Type
Article: article from journal or magazin.
Collection
Publications
Title
Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness.
Journal
Journal of Neuroscience Research
Author(s)
Criego A.B., Tkac I., Kumar A., Thomas W., Gruetter R., Seaquist E.R.
ISSN
0360-4012 (Print)
ISSN-L
0360-4012
Publication state
Published
Issued date
2005
Volume
79
Number
1-2
Pages
42-47
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish. PDF type: Research Article
Abstract
Although it is well established that recurrent hypoglycemia leads to hypoglycemia unawareness, the mechanisms responsible for this are unknown. One hypothesis is that recurrent hypoglycemia alters brain glucose transport or metabolism. We measured steady-state brain glucose concentrations during a glucose clamp to determine whether subjects with type 1 diabetes and hypoglycemia unawareness may have altered cerebral glucose transport or metabolism after exposure to recurrent hypoglycemia. We compared 14 subjects with diabetes and hypoglycemia unawareness to 27 healthy control subjects. Brain glucose concentrations were measured under similar metabolic conditions using in vivo (1)H nuclear magnetic resonance (NMR) spectroscopy at 4 Tesla during a hyperglycemic clamp (plasma glucose = 16.7 mmol/l) with somatostatin and insulin. Subjects with type 1 diabetes and hypoglycemia unawareness had significantly higher brain glucose concentrations compared to that in controls under the same conditions (5.5 +/- 0.3 vs. 4.7 +/- 0.1 micromol/g wet weight, P = 0.016). These data suggest that changes in brain glucose transport or metabolism may occur as a result of recurrent hypoglycemia.
Keywords
Adult, Aged, Blood Glucose/metabolism, Brain/metabolism, Chromatography, High Pressure Liquid/methods, Diabetes Mellitus, Type 1/complications, Diabetes Mellitus, Type 1/metabolism, Epinephrine/metabolism, Female, Glucagon/metabolism, Glucose/metabolism, Glucose Clamp Technique/methods, Humans, Hypoglycemia/etiology, Hypoglycemia/metabolism, Magnetic Resonance Spectroscopy/methods, Male, Middle Aged, Norepinephrine/metabolism, Radioimmunoassay/methods, Recurrence, Tritium/metabolism
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 14:25
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