Secreted proteases from dermatophytes

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Serval ID
serval:BIB_6A67D65DA43D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Secreted proteases from dermatophytes
Journal
Mycopathologia
Author(s)
Monod M.
ISSN
0301-486X
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
166
Number
5-6
Pages
285-294
Language
english
Abstract
Dermatophytes are highly specialized pathogenic fungi that exclusively infect the stratum corneum, nails or hair, and it is evident that secreted proteolytic activity is important for their virulence. Endo- and exoproteases-secreted by dermatophytes are similar to those of species of the genus Aspergillus. However, in contrast to Aspergillus spp., dermatophyte-secreted endoproteases are multiple and are members of two large protein families, the subtilisins (serine proteases) and the fungalysins (metalloproteases). In addition, dermatophytes excrete sulphite as a reducing agent. In the presence of sulphite, disulphide bounds of the keratin substrate are directly cleaved to cysteine and S-sulphocysteine, and reduced proteins become accessible for further digestion by various endo- and exoproteases secreted by the fungi. Sulphitolysis is likely to be an essential step in the digestion of compact keratinized tissues which precedes the action of all proteases.
Keywords
Animals, Exopeptidases, Humans, Keratins, Metalloproteases, Microsporum, Serine Endopeptidases, Sulfites, Trichophyton, Virulence
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2009 16:16
Last modification date
01/10/2019 7:18
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