Restoration of connexin 40 (cx40) in Renin-producing cells reduces the hypertension of cx40 null mice.

Details

Serval ID
serval:BIB_6A5937C56810
Type
Article: article from journal or magazin.
Collection
Publications
Title
Restoration of connexin 40 (cx40) in Renin-producing cells reduces the hypertension of cx40 null mice.
Journal
Hypertension
Author(s)
Le Gal L., Alonso F., Wagner C., Germain S., Nardelli Haefliger D., Meda P., Haefliger J.A.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
63
Number
6
Pages
1198-1204
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Connexin 40 (Cx40) is expressed by the renin-producing cells (RSCs) of the kidneys and the endothelial cells of blood vessels. Cx40 null mice (Cx40(-/-)) feature a much increased renin synthesis and secretion, which results in chronic hypertension, and also display an altered endothelium-dependent relaxation of the aorta because of reduced eNOS levels and nitric oxide production. To discriminate the effect of Cx40 in renin secretion and vascular signaling, we targeted Cx40 to either the RSCs or the endothelial cells of Cx40 null mice. When compared with Cx40(-/-) controls, the animals expressing Cx40 in RSCs were less hypertensive and featured reduced renin levels, still numerous RSCs outside the wall of the afferent arterioles. In contrast, mice expressing Cx40 in the endothelial cells were as hypertensive as Cx40(-/-) mice, in spite of control levels of Cx37 and eNOS. Our data show that blood pressure is improved by restoration of Cx40 expression in RSCs but not in endothelial cells, stressing the prominent role of renin in the mouse hypertension linked to loss of Cx40.
Pubmed
Web of science
Open Access
Yes
Create date
20/06/2014 18:27
Last modification date
20/08/2019 15:25
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