Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_6A18CE0FEBA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance.
Journal
Obesity
Author(s)
Amati F., Pennant M., Azuma K., Dubé J.J., Toledo F.G., Rossi A.P., Kelley D.E., Goodpaster B.H.
ISSN
1930-7381 (Print)
ISSN-L
1930-7381
Publication state
Published
Issued date
2012
Volume
20
Number
5
Pages
1115-1117
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
It is well known that visceral adipose tissue (VAT) is associated with insulin resistance (IR). Considerable debate remains concerning the potential positive effect of thigh subcutaneous adipose tissue (TSAT). Our objective was to observe whether VAT and TSAT are opposite, synergistic or additive for both peripheral and hepatic IR. Fifty-two volunteers (21 male/31 female) between 30 and 75 years old were recruited from the general population. All subjects were sedentary overweight or obese (mean BMI 33.0 ± 3.4 kg/m(2)). Insulin sensitivity was determined by a 4-h hyperinsulinemic-euglycemic clamp with stable isotope tracer dilution. Total body fat and lean body mass were determined by dual X-ray absorptiometry. Abdominal and mid-thigh adiposity was determined by computed tomography. VAT was negatively associated with peripheral insulin sensitivity, while TSAT, in contrast, was positively associated with peripheral insulin sensitivity. Subjects with a combination of low VAT and high TSAT had the highest insulin sensitivity, subjects with a combination of high VAT and low TSAT were the most insulin resistant. These associations remained significant after adjusting for age and gender. These data confirm that visceral excess abdominal adiposity is associated with IR across a range of middle-age to older men and women, and further suggest that higher thigh subcutaneous fat is favorably associated with better insulin sensitivity. This strongly suggests that these two distinct fat distribution phenotypes should both be considered in IR as important determinants of cardiometabolic risk.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-126339
Create date
14/06/2012 19:31
Last modification date
20/01/2020 7:20
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