Differential expression of cell adhesion molecules in inflamed appendix: correlation with clinical stage.

Details

Serval ID
serval:BIB_6A17E0ACB8A5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential expression of cell adhesion molecules in inflamed appendix: correlation with clinical stage.
Journal
Journal of Pathology
Author(s)
Bittinger F., Brochhausen C., Köhler H., Lehr H.A., Otto M., Skarke C., Walgenbach S., Kirkpatrick C.J.
ISSN
0022-3417 (Print)
ISSN-L
0022-3417
Publication state
Published
Issued date
1998
Volume
186
Number
4
Pages
422-428
Language
english
Abstract
The diagnosis of 'early inflamed', 'recurrent' or 'sub-acute' appendicitis is often difficult and accompanied by controversies between clinical data, histological findings, and their interpretation. The expression of the intercellular cell adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1), and E-selectin has been studied in 61 appendicectomy specimens for possible use as a diagnostic tool. This study demonstrates a different expression of CAM by endothelial (EC) and mesothelial cells (MC) in the various stages of appendicitis, with early E-selectin and ICAM-1 expression in EC, followed by VCAM-1 in EC and MC. Appendices from patients with prolonged clinical symptoms defined by clinicians as 'chronic' appendicitis showed VCAM-1 expression and occasionally weak expression of E-selectin in EC. In several cases, discrepancies were found between the pre-operative 'clinical' diagnosis, the histomorphological findings, and the immunohistological results. In this context, the expression of E-selectin and VCAM-1 in comparison with the histological features has potential significance in the diagnosis of 'early acute', 'sub-acute' or 'recurrent' appendicitis. In addition, a correlation was demonstrated between the histological stages of appendicitis and the kinetics of CAM expression. The study also indicates that the time course of E-selectin expression in vivo is longer than is suggested from in vitro data.
Keywords
Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Appendectomy, Appendicitis/metabolism, Appendicitis/pathology, Cell Adhesion Molecules/metabolism, Chronic Disease, E-Selectin/metabolism, Female, Humans, Immunoenzyme Techniques, Intercellular Adhesion Molecule-1/metabolism, Male, Middle Aged, Recurrence, Vascular Cell Adhesion Molecule-1/metabolism
Pubmed
Create date
25/11/2011 19:40
Last modification date
20/08/2019 14:24
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