Treatment of streptococcal endocarditis with a single daily dose of ceftriaxone and netilmicin for 14 days: a prospective multicenter study

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_6A1300230FCF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of streptococcal endocarditis with a single daily dose of ceftriaxone and netilmicin for 14 days: a prospective multicenter study
Journal
Clinical Infectious Diseases
Author(s)
Francioli  P., Ruch  W., Stamboulian  D.
ISSN
1058-4838 (Print)
Publication state
Published
Issued date
12/1995
Volume
21
Number
6
Pages
1406-10
Language
english
Notes
Clinical Trial
Journal Article
Multicenter Study --- Old month value: Dec
Abstract
A 2-week course of ceftriaxone (2 g) plus netilmicin (4 mg/kg), administered as one short daily iv infusion, was evaluated for the treatment of streptococcal endocarditis in an open multicenter study. Of the 52 patients, 31 were infected with viridans streptococci, 18 with Streptococcus bovis, two with Gemella morbillorum, and one with group C Streptococcus; 48 patients were assessable. Infection was cured in 42 cases, 35 treated medically and seven treated both medically and surgically. Five patients died without evidence of active infection, and one relapsed. The bacteriologic failure was due to a strain of G. morbillorum against which no synergy of ceftriaxone and netilmicin was evident in vitro. The serum creatinine level increased during treatment in four cases, all involving patients > 65 years old who had renal risk factors; in two of these cases, values did not return to baseline during follow-up. Of 40 patients assessed for auditory function, only one developed decreased perception of borderline significance. Other adverse reactions were mild. This regimen was efficacious, safe, and cost-effective for the treatment of streptococcal endocarditis. However, it must be used with caution for patients with preexisting renal impairment or concomitant exposure to other potentially nephrotoxic agents.
Keywords
Adolescent Adult Aged Aged, 80 and over Ceftriaxone/*therapeutic use Drug Therapy, Combination Endocarditis, Bacterial/*drug therapy/microbiology Female Follow-Up Studies Humans Male Middle Aged Netilmicin/*therapeutic use Prospective Studies Streptococcal Infections/*drug therapy/microbiology Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 18:08
Last modification date
01/10/2019 7:18
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