Ten Years of Collaborative Progress in the Quest for Orthologs.
Details
Serval ID
serval:BIB_69FF3D639B70
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ten Years of Collaborative Progress in the Quest for Orthologs.
Journal
Molecular biology and evolution
Working group(s)
QFO Consortium
Contributor(s)
Altenhoff A., Ouangraoua A., Vesztrocy A.W., Linard B., Dessimoz C., Szklarczyk D., Durand D., Emms D., Moi D., Thybert D., Sonnhammer E., Kriventseva E., Tang H., Chiba H., Uchiyama I., Ebersberger I., Huerta-Cepas J., Fernandez-Breis J.T., Blake J.A., Pryszcz L., Martin M.J., Houben M.M., Patricio M., Muffato M., Glover N., Lecompte O., Thomas P.D., Schiffer P., Capella-Gutierrez S., Cosentino S., McGlynn S.E., Kuraku S., Forslund S., Kelly S., Lewis S., Jones T., de Farias T.M., Maeda T., Gabaldon T., Iwasaki W., Pearson W., Wang Y., Nevers Y., Hara Y.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Publication state
Published
Issued date
29/07/2021
Peer-reviewed
Oui
Volume
38
Number
8
Pages
3033-3045
Language
english
Notes
Publication types: Congress ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology-evolutionary relatedness-is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit-from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses.
Keywords
Genetic Speciation, Genome, Viral, Genomics/methods, Genomics/trends, Phylogeny, gene models, orthology, paralogy, phylogenetic profiling, viruses, xenology
Pubmed
Web of science
Open Access
Yes
Create date
12/04/2021 14:52
Last modification date
23/01/2024 8:27