Positioning Europe for the EPITRANSCRIPTOMICS challenge.

Details

Serval ID
serval:BIB_69FDFD07375D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Positioning Europe for the EPITRANSCRIPTOMICS challenge.
Journal
RNA biology
Author(s)
Jantsch M.F., Quattrone A., O'Connell M., Helm M., Frye M., Macias-Gonzales M., Ohman M., Ameres S., Willems L., Fuks F., Oulas A., Vanacova S., Nielsen H., Bousquet-Antonelli C., Motorin Y., Roignant J.Y., Balatsos N., Dinnyes A., Baranov P., Kelly V., Lamm A., Rechavi G., Pelizzola M., Liepins J., Holodnuka Kholodnyuk I., Zammit V., Ayers D., Drablos F., Dahl J.A., Bujnicki J., Jeronimo C., Almeida R., Neagu M., Costache M., Bankovic J., Banovic B., Kyselovic J., Valor L.M., Selbert S., Pir P., Demircan T., Cowling V., Schäfer M., Rossmanith W., Lafontaine D., David A., Carre C., Lyko F., Schaffrath R., Schwartz S., Verdel A., Klungland A., Purta E., Timotijevic G., Cardona F., Davalos A., Ballana E., O Carroll D., Ule J., Fray R.
ISSN
1555-8584 (Electronic)
ISSN-L
1547-6286
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
15
Number
6
Pages
829-831
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
Keywords
DNA, Neoplasm/genetics, DNA, Neoplasm/metabolism, Epigenesis, Genetic, Epigenomics/standards, Europe, Gene Expression Profiling/methods, Gene Expression Profiling/standards, Gene Expression Regulation, Neoplastic, Humans, Neoplasms/genetics, Neoplasms/metabolism, RNA, Neoplasm/genetics, RNA, Neoplasm/metabolism, Transcriptome, European funding, database of Modification, detection of RNA modification, epitranscriptomics, model systems
Pubmed
Web of science
Open Access
Yes
Create date
28/10/2019 12:40
Last modification date
29/10/2019 6:26
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