Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis.

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Version: Final published version
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Serval ID
serval:BIB_69E2294C6624
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis.
Journal
Journal of Clinical Oncology
Author(s)
Guillou L., Benhattar J., Bonichon F., Gallagher G., Terrier P., Stauffer E., Somerhausen Nde S, Michels J.J., Jundt G., Vince D.R., Taylor S., Genevay M., Collin F., Trassard M., Coindre J.M.
ISSN
0732-183X
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
22
Number
20
Pages
4040-4050
Language
english
Abstract
PURPOSE: To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS). PATIENTS AND METHODS: Data on 165 patients with SS (141 with localized disease at diagnosis) were studied retrospectively. The following parameters were examined for their potential prognostic value: age at diagnosis, sex, tumor site (extremities v proximal/truncal), size, histology, mitotic count, necrosis, histologic grade (Federation Nationale des Centres de Lutte Contre le Cancer system), stage (1997 tumor-node-metastasis system classification), surgical margin status (assessed histologically), and fusion type (SYT-SSX1 v SYT-SSX2). Median follow-up time was 37 months (range, 2 to 302 months). RESULTS: Among those patients with localized disease at diagnosis, median and 5-year disease-specific survivals (DSS) for the SYT-SSX1 and SYT-SSX2 subgroups were 126 months and 67.4% versus 82 months and 63.2%, respectively (P = .12). Median and 5-year metastasis-free survivals (MFS) were 84 months and 54.2% for SYT-SSX1 versus 50 months and 47.6% for SYT-SSX2 (P = .76). Univariate analyses showed that high histologic grade (grade 3), high mitotic count (>/= 10 mitoses/10 high-power fields), stage III disease, size greater than 7 cm, tumor necrosis, and presence of areas of poorly differentiated morphology were significant adverse prognostic factors for DSS and MFS, whereas SYT-SSX fusion type, tumor histology (biphasic v monophasic), and patient sex were not. Age greater than 35 years adversely affected DSS but not MFS. In multivariate analyses, histologic grade was the most significant prognostic factor for both DSS and MFS. CONCLUSION: For patients with localized SS, histologic grade but not SYT-SSX fusion type is a strong predictor of survival.
Keywords
Adolescent, Adult, Age Factors, Child, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm Metastasis, Oncogene Proteins, Fusion/genetics, Prognosis, Proportional Hazards Models, Retrospective Studies, Sarcoma, Synovial/diagnosis, Sarcoma, Synovial/pathology, Survival Rate, Tumor Markers, Biological/analysis
Pubmed
Web of science
Create date
29/01/2008 19:34
Last modification date
14/07/2020 6:21
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