Episodic memory decline in Parkinson' s disease: relation with white matter hyperintense lesions and influence of quantification method.

Details

Serval ID
serval:BIB_69E19153E20D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Episodic memory decline in Parkinson' s disease: relation with white matter hyperintense lesions and influence of quantification method.
Journal
Brain imaging and behavior
Author(s)
Dunet V., Fartaria M.J., Deverdun J., Le Bars E., Maury F., Castelnovo G., Kober T., Cuadra M.B., Geny C., Marechal B., de Champfleur N.M.
ISSN
1931-7565 (Electronic)
ISSN-L
1931-7557
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
13
Number
3
Pages
810-818
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The relation of white matter hyperintense lesions to episodic memory impairment in patients with Parkinson's disease (PD) is still controversial. We aimed at evaluating the relation between white matter hyperintense lesions and episodic memory decline in patients with PD. In this multicentric prospective study, twenty-one normal controls, 15 PD patients without mild cognitive impairment (MCI) and 13 PD patients with MCI were selected to conduct a clinico-radiological correlation analysis. Performance during episodic memory testing, age-related white matter changes score, total manual and automated white matter hyperintense lesions volume and lobar white matter hyperintense lesions volumes were compared between groups using the Kruskal-Wallis and Wilcoxon signed-rank tests, and correlations were assessed using the Spearman test. MCI PD patients had impaired free recall. They also had higher total, left prefrontal and left temporal white matter hyperintense lesions volumes than normal controls. Free recall performance was negatively correlated with the total white matter hyperintense lesions volume, either manually or automatically delineated, but not with the age-related white matter changes score. Using automated segmentation, both the left prefrontal and temporal white matter hyperintense lesions volumes were negatively correlated with the free recall performance. Early episodic memory impairment in MCI PD patients may be related to white matter hyperintense lesions, mainly in the prefrontal and temporal lobes. This relation is influenced by the method used for white matter hyperintense lesions quantification. Automated volumetry allows for detecting those changes.
Keywords
Aged, Aged, 80 and over, Brain/physiopathology, Cognition/physiology, Cognitive Dysfunction/pathology, Dementia/pathology, Disease Progression, Female, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Male, Memory Disorders/pathology, Memory, Episodic, Mental Recall/physiology, Parkinson Disease/physiopathology, Prospective Studies, White Matter/pathology, Episodic memory, MRI, Parkinson’s disease, Quantification, White matter hyperintense lesions
Pubmed
Web of science
Open Access
Yes
Create date
28/06/2018 17:39
Last modification date
16/11/2019 7:16
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