Brain energetics (thought needs food).

Details

Serval ID
serval:BIB_69DDBD0890D8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Brain energetics (thought needs food).
Journal
Current opinion in clinical nutrition and metabolic care
Author(s)
Pellerin L.
ISSN
1363-1950
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
11
Number
6
Pages
701-705
Language
english
Abstract
PURPOSE OF REVIEW: Almost 15 years after its initial proposal, the astrocyte-neuron lactate shuttle hypothesis still occupies the center stage in research on brain energetics. Recent developments have provided further evidence for its validity and have extended its application to different areas of neuroscience. RECENT FINDINGS: Description of cell-specific metabolic characteristics have reinforced the view that a prominent conversion of glucose into lactate takes place in astrocytes, whereas neurons preferentially take up and oxidize lactate over glucose-derived pyruvate. Indeed, specific mechanisms are activated by glutamatergic activity to favor such a net lactate transfer between the two cell types. Moreover, demonstration in vivo of the existence and implication of the astrocyte-neuron lactate shuttle hypothesis for particular neurophysiological processes is beginning to appear. SUMMARY: Brain energetics has undertaken its revolution. A new concept based on metabolic compartmentalization between astrocytes and neurons is establishing itself as the leading paradigm that opens new perspectives in areas such as functional brain imaging and regulation of energy homeostasis.
Keywords
Astrocytes, Brain, Energy Metabolism, Glucose, Humans, Lactic Acid, Neurons, Nutritional Requirements
Pubmed
Web of science
Create date
31/03/2009 16:42
Last modification date
20/08/2019 14:24
Usage data