Natriuretic Peptide Receptor B modulates the proliferation of the cardiac cells expressing the Stem Cell Antigen-1.

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Ressource 1Download: srep41936.pdf (1908.68 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_69B7FAE7AAC0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Natriuretic Peptide Receptor B modulates the proliferation of the cardiac cells expressing the Stem Cell Antigen-1.
Journal
Scientific reports
Author(s)
Rignault-Clerc S., Bielmann C., Liaudet L., Waeber B., Feihl F., Rosenblatt-Velin N.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
09/02/2017
Peer-reviewed
Oui
Volume
7
Pages
41936
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Brain Natriuretic Peptide (BNP) injections in adult "healthy" or infarcted mice led to increased number of non-myocyte cells (NMCs) expressing the nuclear transcription factor Nkx2.5. The aim of this study was to identify the nature of the cells able to respond to BNP as well as the signaling pathway involved. BNP treatment of neonatal mouse NMCs stimulated Sca-1 <sup>+</sup> cell proliferation. The Sca-1 <sup>+</sup> cells were characterized as being a mixed cell population involving fibroblasts and multipotent precursor cells. Thus, BNP treatment led also to increased number of Sca-1 <sup>+</sup> cells expressing Nkx2.5, in Sca-1 <sup>+</sup> cell cultures in vitro and in vivo, in the hearts of neonatal and adult infarcted mice. Whereas BNP induced Sca-1 <sup>+</sup> cell proliferation via NPR-B receptor and protein kinase G activation, CNP stimulated Sca-1 <sup>+</sup> cell proliferation via NPR-B and a PKG-independent mechanism. We highlighted here a new role for the natriuretic peptide receptor B which was identified as a target able to modulate the proliferation of the Sca-1 <sup>+</sup> cells. The involvement of NPR-B signaling in heart regeneration has, however, to be further investigated.
Keywords
Animals, Ataxin-1/genetics, Ataxin-1/metabolism, Cell Proliferation, Cells, Cultured, Cyclic GMP-Dependent Protein Kinases/metabolism, Homeobox Protein Nkx-2.5/metabolism, Mice, Mice, Inbred C57BL, Myocardium/cytology, Natriuretic Peptide, Brain/drug effects, Receptors, Atrial Natriuretic Factor/metabolism, Signal Transduction, Stem Cells/drug effects, Stem Cells/metabolism, Stem Cells/physiology
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2017 19:19
Last modification date
20/08/2019 14:24
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