Affective lability in parents with schizophrenia or bipolar disorder and their co-parents - The Danish High Risk and Resilience Study VIA 7.

Details

Ressource 1Download: 36773417.pdf (485.85 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_699FF59A6612
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Affective lability in parents with schizophrenia or bipolar disorder and their co-parents - The Danish High Risk and Resilience Study VIA 7.
Journal
Psychiatry research
Author(s)
Steffensen N.L., Hemager N., Bundgaard A.F., Gantriis D.L., Burton B.K., Ellersgaard D., Carlsen A.H., Bliksted V., Plessen K.J., Jepsen JRM, Nordentoft M., Thorup AAE, Mors O., Greve A.N.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
03/2023
Peer-reviewed
Oui
Volume
321
Pages
115092
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In bipolar disorder, dysregulation of affect is a core feature while knowledge on affective lability in schizophrenia is sparse. Research on affective lability in partners to individuals with schizophrenia or bipolar disorder is also lacking. The objective of this study was to investigate affective lability in parents with schizophrenia or bipolar disorder, and their co-parents without these disorders. The Danish High Risk and Resilience Study - VIA 7 is a population-based cohort study. This study focuses on parents diagnosed with schizophrenia (n = 148), their co-parents (n = 157), parents with bipolar disorder (n = 98), their co-parents (n = 89) and control parents (n = 359). The Affective Lability Scale - short form (ALS-SF) was used to measure affective lability. We found significantly higher levels of affective lability in parents with schizophrenia and bipolar disorder compared with controls, but no significant differences between bipolar disorder and schizophrenia. Co-parents to parents with schizophrenia had significantly higher levels of affective lability compared to controls. Our results add to the existing knowledge concerning underlying transdiagnostic factors and nonrandom mating in schizophrenia and bipolar disorder and highlight the need for studies of parental affective lability as a potential risk factor for offspring in families with parental schizophrenia or bipolar disorder.
Keywords
Humans, Bipolar Disorder/psychology, Schizophrenia, Cohort Studies, Parents, Denmark, Assortative mating, Bipolar disorder, Mental disorders, Nonrandom mating
Pubmed
Web of science
Open Access
Yes
Create date
14/02/2023 13:34
Last modification date
16/11/2023 8:17
Usage data