Diagnostic accuracy of nuclear medicine imaging in protein losing enteropathy : systematic review and meta-analysis of the literature.

Details

Serval ID
serval:BIB_699AFD9E994C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic accuracy of nuclear medicine imaging in protein losing enteropathy : systematic review and meta-analysis of the literature.
Journal
Acta gastro-enterologica Belgica
Author(s)
Khalesi M., Nakhaei A.A., Seyed A.J., Treglia G., Zakavi S.R., Sadeghi R., Kianifar H.R.
ISSN
1784-3227 (Print)
ISSN-L
1784-3227
Publication state
Published
Issued date
12/2013
Peer-reviewed
Oui
Volume
76
Number
4
Pages
413-422
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Scintigraphy using Tc-99m or In-111 labeled proteins is an important diagnostic modality for diagnosis of protein losing enteropathy (PLE). We systematically reviewed the available literature regarding the accuracy of scintigraphy using Tc-99m or In-111 labeled proteins for diagnosis of PLE.
Medline and SCOPUS were searched using (("protein losing") AND ("scintigraphy" OR "Nuclear Medicine")) as keywords without any language or date limit. All studies on the accuracy of scintigraphy using Tc-99m or In-111 labeled proteins in PLE were included in the systematic review.
Overall 12 studies were included in our study. Pooled sensitivity and specificity were 87% [81-92%], and 62% [51-72%], respectively. Tc-99m labeled tracers had higher sensitivity but lower specificity compared to In-111 labeled ones. Delayed imaging could increase the sensitivity of imaging despite the lower specificity compared to the early images. Restriction of the analyses to larger studies (more than 10 patients) and to studies with the gold standard of fecal alphal-antitrypsin did not change the pooled indices.
Scintigraphy using Tc-99m or In-111 labeled proteins has high sensitivity for diagnosis and localization of PLE. Using Tc-99m labeled tracers and delayed imaging can further increase the sensitivity. Despite the high sensitivity, specificity of scintigraphy is suboptimal and false positive abdominal activities can limit the usefulness of this imaging method.

Keywords
Diagnostic Imaging/methods, Humans, Nuclear Medicine/methods, Protein-Losing Enteropathies/diagnostic imaging, Radionuclide Imaging, Reproducibility of Results
Pubmed
Web of science
Create date
20/08/2017 19:34
Last modification date
20/08/2019 15:24
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