Traitement combiné d'insuline et d'analogue du GLP-1: qu'en attendre [Combined treatment of insulin and GLP-1 analogs: what do we expect?].
Details
Serval ID
serval:BIB_698E4ADC87DC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Traitement combiné d'insuline et d'analogue du GLP-1: qu'en attendre [Combined treatment of insulin and GLP-1 analogs: what do we expect?].
Journal
Revue Médicale Suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2014
Volume
10
Number
433
Pages
1235-6, 1238-40
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
Type 2 diabetes mellitus is a progressive and heterogeneous disease. The decrease in insulin secretion by pancreatic beta cells and the increase of glucagon secretion by pancreatic beta cells, are the two major pathophysiologic characteristics. The majority of type 2 diabetics will therefore require insulin in the evolution of their disease, with weight gain and hypoglycaemia as side effects. GLP-1 analogs are effective therapeutic alternatives due to their actions on glucagon and insulin secretion, on satiety and gastric emptying. For patients inadequately controlled with conventional antidiabetics, GLP-1 analogs, introduced as an alternative or in combination with insulin, can prevent or reduce the side effects associated with insulin. Indeed, the risk of hypoglycaemia is reduced and the vicious circle of weight gain secondary to insulin/need to increase insulin doses is limited.
Keywords
Diabetes Mellitus, Type 2/drug therapy, Diabetes Mellitus, Type 2/etiology, Drug Therapy, Combination, Glucagon-Like Peptide 1/analogs & derivatives, Humans, Hypoglycemic Agents/administration & dosage, Incretins/administration & dosage, Insulin/administration & dosage, Molecular Targeted Therapy
Pubmed
Create date
10/09/2015 12:59
Last modification date
20/08/2019 15:24