Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.

Details

Ressource 1Download: Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment.pdf (2406.54 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_6984A7C83F93
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.
Journal
Alzheimer's & dementia
Author(s)
Delvenne A., Gobom J., Tijms B., Bos I., Reus L.M., Dobricic V., Kate M.T., Verhey F., Ramakers I., Scheltens P., Teunissen C.E., Vandenberghe R., Schaeverbeke J., Gabel S., Popp J., Peyratout G., Martinez-Lage P., Tainta M., Tsolaki M., Freund-Levi Y., Lovestone S., Streffer J., Barkhof F., Bertram L., Blennow K., Zetterberg H., Visser P.J., Vos SJB
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
14/06/2022
Peer-reviewed
Oui
Volume
19
Number
3
Pages
807-820
Language
english
Notes
Publication types: Journal Article
Abstract
Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker concept that encompasses individuals with neuronal injury but without amyloidosis. We aim to investigate the pathophysiology of SNAP, defined as abnormal tau without amyloidosis, in individuals with mild cognitive impairment (MCI) by cerebrospinal fluid (CSF) proteomics.
Individuals were classified based on CSF amyloid beta (Aβ)1-42 (A) and phosphorylated tau (T), as cognitively normal A-T- (CN), MCI A-T+ (MCI-SNAP), and MCI A+T+ (MCI-AD). Proteomics analyses, Gene Ontology (GO), brain cell expression, and gene expression analyses in brain regions of interest were performed.
A total of 96 proteins were decreased in MCI-SNAP compared to CN and MCI-AD. These proteins were enriched for extracellular matrix (ECM), hemostasis, immune system, protein processing/degradation, lipids, and synapse. Fifty-one percent were enriched for expression in the choroid plexus.
The pathophysiology of MCI-SNAP (A-T+) is distinct from that of MCI-AD. Our findings highlight the need for a different treatment in MCI-SNAP compared to MCI-AD.
Keywords
Alzheimer's disease, biomarkers, cerebrospinal fluid, mild cognitive impairment, pathophysiology, proteomics, suspected non-Alzheimer's disease pathophysiology, tau
Pubmed
Web of science
Create date
21/06/2022 13:11
Last modification date
21/11/2023 8:10
Usage data