Importance of genotypic and phenotypic tolerance in the treatment of experimental endocarditis due to Streptococcus gordonii.

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Serval ID
serval:BIB_6970AFC7FCFD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Importance of genotypic and phenotypic tolerance in the treatment of experimental endocarditis due to Streptococcus gordonii.
Journal
Journal of Infectious Diseases
Author(s)
Entenza J.M., Caldelari I., Glauser M.P., Francioli P., Moreillon P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1997
Volume
175
Number
1
Pages
70-76
Language
english
Abstract
Genotypic and phenotypic tolerance was studied in penicillin treatment of experimental endocarditis due to nontolerant and tolerant Streptococcus gordonii and to their backcross transformants. The organisms were matched for in vitro and in vivo growth rates. Rats with aortic endocarditis were treated for 3 or 5 days, starting 12, 24, or 48 h after inoculation. When started at 12 h, during fast intravegetation growth, 3 days of treatment cured 80% of the nontolerant parent compared with <30% of the tolerant derivative (P < .005). When started at 24 or 48 h and if intravegetation growth had reached a plateau, 3 days of treatment failed against both bacteria. However, a significant difference between the 2 organisms was restored when treatment was extended to 5 days. Thus, genotypic tolerance conferred a survival advantage in both fast- and slow-growing bacteria, demonstrating that the in vitro-defined tolerant phenotype also carried the risk of treatment failure in vivo.
Keywords
Animals, Anti-Bacterial Agents/pharmacology, Aortic Valve/microbiology, Bacteremia/microbiology, Drug Resistance, Microbial, Drug Tolerance, Endocarditis, Bacterial/drug therapy, Endocarditis, Bacterial/microbiology, Female, Genotype, Microbial Sensitivity Tests, Mutation, Penicillins/blood, Penicillins/pharmacology, Phenotype, Rats, Rats, Wistar, Serum Bactericidal Test, Spleen/microbiology, Streptococcal Infections/drug therapy, Streptococcal Infections/microbiology, Streptococcus/drug effects, Streptococcus/genetics, Streptococcus sanguis/drug effects, Streptococcus sanguis/genetics, Streptomycin/pharmacology, Transformation, Bacterial, Treatment Failure
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:45
Last modification date
25/09/2019 7:09
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