Appropriateness of early management of newly diagnosed Crohn's disease in a European population-based cohort.

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State: Public
Version: author
Serval ID
serval:BIB_696479B25EEB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Appropriateness of early management of newly diagnosed Crohn's disease in a European population-based cohort.
Journal
Scandinavian Journal of Gastroenterology
Author(s)
Juillerat P., Pittet V., Mottet C., Felley C., Gonvers J.J., Vader J.P., Burnand B., Froehlich F., Wolters F.L., Stockbrügger R.W., Michetti P.
Working group(s)
EC-IBD Group
Contributor(s)
Wolters FL., Russel MG., Stockbrügger RW., Cilissen M., Romberg M., Freitas J., Nunes PB., Binder V., Munkholm P., Riis L., Langholz E., Politi P., Bodini P., O'Morain C., Qasim A., Harrington A., d'Albasio G., Messori A., Wessels F., van Hees E., van Hees R., Nap M., Pallis A., Vlachonikolis I., Mouzas IA., Koutroubakis I., Tzardi M., Tsianos E., Katsanos K., Economou M., Rutgeerts P., Vermeire S., Joossens S., Claessens G., Limonard C., van Zeijil G., Ranzi T., Cortelezzi C., Vatn M., Lygren I., Bernklev T., Moum£££Bjørn£££ B. , Solberg C., Høie O., Fornaciari G., Mortilla MG., Beltrami M., Pera A., Rodriguez D., Clofent J., Butron M., Odes S., Monteiro E.
ISSN
1502-7708 (Electronic)
ISSN-L
0036-5521
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
45
Number
12
Pages
1449-1456
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECTIVE: The European Panel on the Appropriateness of Crohn's disease Therapy (EPACT) has developed appropriateness criteria. We have applied these criteria retrospectively to the population-based inception cohort of Crohn's disease (CD) patients of the European Collaborative Study Group on Inflammatory Bowel Disease (EC-IBD).
MATERIAL AND METHODS: A total of 426 diagnosed CD patients from 13 European centers were enrolled at the time of diagnosis (first flare, naive patients). We used the EPACT definitions to identify 247 patients with active luminal CD. We then assessed the appropriateness of the initial drug prescription according to the EPACT criteria.
RESULTS: Among the cohort patients 163 suffered from mild-to-moderate CD and 84 from severe CD. Among the mild-to-moderate disease group, 96 patients (59%) received an appropriate treatment, whereas for 66 patients (40%) the treatment was uncertain and in one case (1%) inappropriate. Among the severe disease group, 86% were treated medically and 14% required surgery. 59 (70%) were appropriately treated, whereas for one patient (1%) the procedure was considered uncertain and for 24 patients (29%) inappropriate.
CONCLUSION: Initial treatment was appropriate in the majority of cases for non-complicated luminal CD. Inappropriate or uncertain treatment was given in a significant minority of patients, with an increased potential risk of adverse events.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Crohn Disease/diagnosis, Crohn Disease/therapy, Europe, Female, Guideline Adherence, Humans, Male, Middle Aged, Physician's Practice Patterns, Quality Assurance, Health Care, Retrospective Studies
Pubmed
Web of science
Create date
30/11/2010 17:57
Last modification date
20/08/2019 15:24
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