Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura

Details

Serval ID
serval:BIB_695D9F245602
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura
Journal
New England Journal of Medicine
Author(s)
Girardin  E., Grau  G. E., Dayer  J. M., Roux-Lombard  P., Lambert  P. H.
ISSN
0028-4793
Publication state
Published
Issued date
08/1988
Peer-reviewed
Oui
Volume
319
Number
7
Pages
397-400
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 18
Abstract
Because of the possible involvement of cytokines in gram-negative septicemia, we investigated serum levels of tumor necrosis factor alpha, interleukin-1 beta, alpha interferon, and gamma interferon in children with gram-negative sepsis and purpura fulminans. We studied 55 patients (ages, 1 month to 19 years) with a clinical diagnosis of sepsis and purpuric lesions who were in shock or had three or more other biologic risk factors. The mortality rate was correlated with the number of risk factors present on admission to the hospital (P = 0.03). Tumor necrosis factor alpha was elevated in 91 percent of the 35 patients tested, interleukin-1 in 21 percent of the 33 patients tested, and gamma interferon in 19 percent of the 32 tested. Alpha interferon levels were within normal limits in the 32 patients tested. Serum levels of tumor necrosis factor alpha were positively correlated with the number of risk factors (P less than 0.05) and negatively correlated with blood fibrinogen levels (P = 0.01). Tumor necrosis factor alpha, interleukin-1, and gamma interferon were significantly higher in patients who died than in the survivors. Alpha interferon levels were similar in the two groups. Serum concentrations of both interleukin-1 and gamma interferon were correlated with concentrations of tumor necrosis factor alpha. These data provide evidence that serum levels of tumor necrosis factor alpha, interleukin-1, and gamma interferon correlate with the severity of meningococcemia in children. The findings may have implications for new therapeutic approaches.
Keywords
Adolescent Adult Child Child, Preschool Fibrinogen/analysis Humans Infant Infant, Newborn Infection/*blood/mortality Interferon Type I/blood Interferon Type II/blood Interleukin-1/*analysis Purpura/*blood/etiology/mortality Risk Factors Tumor Necrosis Factor-alpha/*blood
Pubmed
Web of science
Create date
15/01/2008 14:28
Last modification date
20/08/2019 14:24
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