A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

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Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_6912B8DACE03
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.
Journal
The Journal of experimental medicine
Author(s)
Traversari C., van der Bruggen P., Luescher I.F., Lurquin C., Chomez P., Van Pel A., De Plaen E., Amar-Costesec A., Boon T.
ISSN
0022-1007
Publication state
Published
Issued date
1992
Peer-reviewed
Oui
Volume
176
Number
5
Pages
1453-1457
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We have reported the identification of human gene MAGE-1, which directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes (CTL). We show here that CTL directed against this antigen, which was named MZ2-E, recognize a nonapeptide encoded by the third exon of gene MAGE-1. The CTL also recognize this peptide when it is presented by mouse cells transfected with an HLA-A1 gene, confirming the association of antigen MZ2-E with the HLA-A1 molecule. Other members of the MAGE gene family do not code for the same peptide, suggesting that only MAGE-1 produces the antigen recognized by the anti-MZ2-E CTL. Our results open the possibility of immunizing HLA-A1 patients whose tumor expresses MAGE-1 either with the antigenic peptide or with autologous antigen-presenting cells pulsed with the peptide.
Keywords
Amino Acid Sequence, Antigens, Neoplasm/genetics, Base Sequence, HLA-A1 Antigen/immunology, Humans, Melanoma/immunology, Molecular Sequence Data, Oligopeptides/analysis, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:19
Last modification date
20/08/2019 14:24
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