Controlled dynamic generation of standard 1,6-hexamethylene diisocyanate aerosols

Details

Serval ID
serval:BIB_6908CEC7E128
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Controlled dynamic generation of standard 1,6-hexamethylene diisocyanate aerosols
Journal
Annals of Occupational Hygiene
Author(s)
Huynh Cong Khanh, Vu Duc Trinh, Savolainen Heikki
ISSN
0003-4878 (Print)
ISSN-L
0003-4878
Publication state
Published
Issued date
1989
Volume
33
Number
4
Pages
573-581
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
A procedure for the dynamic generation of 1,6-hexamethylene diisocyanate (HDI) aerosol atmospheres of 70 micrograms m-3 (0.01 ppm) to 1.75 mg m-3 (0.25 ppm), based on the precise control of the evaporation of pure liquid HDI and subsequent dilution with air, was developed. The apparatus consisted of a home-made glass nebulizer coupled with a separation stage to exclude non-respirable droplets (greater than 10 microns). The aerosol concentrations were achieved by passing air through the nebulizer at 1.5-4.5 l. min-1 to generate dynamically 0.01-0.25 ppm of diisocyanate in an experimental chamber of 8.55 m3. The distribution of the liquid aerosol was established with an optical counter and the diisocyanate concentration was determined from samples collected in impingers by a high-pressure liquid chromatographic method. The atmospheres generated were suitable for the evaluation both of sampling procedures full scale, and of analytical methods: at 140 micrograms m-3 (0.02 ppm) they remained stable for 15-min provocation tests in clinical asthma, as verified by breath-zone sampling of exposed patients.
Keywords
Aerosols/analysis, Bronchial Provocation Tests/instrumentation, Bronchial Provocation Tests/methods, Cyanates/analysis, Humans, Nebulizers and Vaporizers
Pubmed
Web of science
Create date
30/10/2012 14:33
Last modification date
20/08/2019 14:24
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