Long-duration response to levodopa in patients with advanced Parkinson disease treated with subthalamic deep brain stimulation.

Details

Serval ID
serval:BIB_68FD6FA9DEB9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Long-duration response to levodopa in patients with advanced Parkinson disease treated with subthalamic deep brain stimulation.
Journal
Archives of Neurology
Author(s)
Wider C., Russmann H., Villemure J.G., Robert B., Bogousslavsky J., Burkhard P.R., Vingerhoets F.J.
ISSN
0003-9942 (Print)
ISSN-L
0003-9942
Publication state
Published
Issued date
2006
Volume
63
Number
7
Pages
951-955
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Long-duration response (LDR) to levodopa is supposed to decrease with Parkinson disease (PD) progression, but direct observation of this response in advanced PD has never been performed.
OBJECTIVE: To study the LDR to levodopa in patients with advanced PD treated with subthalamic deep brain stimulation (DBS).
DESIGN AND SETTING: We studied 30 consecutive patients with PD who underwent subthalamic DBS. One group had no antiparkinsonian treatment since surgery (no-levodopa group), whereas medical treatment had to be reinitiated in the other group (levodopa group).
MAIN OUTCOME MEASURE: Motor subscale score of the Unified Parkinson's Disease Rating Scale.
RESULTS: Compared with preoperative assessment, evaluation 6 months postoperatively with DBS turned off for 3 hours found a worsening of the motor subscale score of the Unified Parkinson's Disease Rating Scale in the no-levodopa group. This worsening being absent in the levodopa group, it probably reflected the loss of the LDR to levodopa in the no-levodopa group. When DBS was turned on, postoperative motor subscale scores of the Unifid Parkinson's Disease Rating Scale in both groups were similar to preoperative scores while receiving medication, suggesting that subthalamic DBS compensated for the short-duration response and LDR to levodopa.
CONCLUSIONS: Our results suggest that the LDR to levodopa remains significant even in advanced PD, and that subthalamic DBS compensates for the short-duration response and LDR to levodopa.
Keywords
Aged, Antiparkinson Agents/administration & dosage, Combined Modality Therapy, Deep Brain Stimulation, Female, Humans, Levodopa/administration & dosage, Male, Middle Aged, Parkinson Disease/drug therapy, Prospective Studies, Severity of Illness Index, Subthalamic Nucleus, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:49
Last modification date
20/08/2019 14:24
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