Three-phase 18F-fluorocholine PET/CT in the evaluation of prostate cancer recurrence.

Details

Serval ID
serval:BIB_68C28C2F9CA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Three-phase 18F-fluorocholine PET/CT in the evaluation of prostate cancer recurrence.
Journal
Nuklearmedizin. Nuclear medicine
Author(s)
Steiner C.h., Vees H., Zaidi H., Wissmeyer M., Berrebi O., Kossovsky M.P., Khan H.G., Miralbell R., Ratib O., Buchegger F.
ISSN
0029-5566
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
48
Number
1
Pages
1-9; quiz N2-3
Language
english
Abstract
AIM: Contribution of 3-phase 18F-fluorocholine PET/CT in suspected prostate cancer recurrence at early rise of PSA. PATIENTS, METHODS: Retrospective analysis was performed in 47 patients after initial treatment with radiotherapy (n=30) or surgery (n=17). Following CT, 10 minutes list-mode PET acquisition was done over the prostate bed after injection of 300 MBq of 18F-fluorocholine. Three timeframes of 3 minutes each were reconstructed for analysis. All patients underwent subsequent whole body PET/CT. Delayed pelvic PET/CT was obtained in 36 patients. PET/CT was interpreted visually by two observers and SUVmax determined for suspicious lesions. Biopsies were obtained from 13 patients. RESULTS: Biopsies confirmed the presence of cancer in 11 of 13 patients with positive PET for a total of 15 local recurrences in which average SUVmax increased during 14 minutes post injection and marginally decreased in delayed scanning. Conversely inguinal lymph nodes with mild to moderate metabolic activity on PET showed a clearly different pattern with decreasing SUVmax on dynamic images. Three-phase PET/CT contributed to the diagnostic assessment of 10 of 47 patients with biological evidence of recurrence of cancer. It notably allowed the discrimination of confounding blood pool or urinary activity from suspicious hyperactivities. PET/CT was positive in all patients with PSA>or=2 ng/ml (n=34) and in 4/13 patients presenting PSA values<2 ng/ml. CONCLUSION: 18F-fluorocholine 3-phase PET/CT showed a progressively increasing SUVmax in biopsy confirmed cancer lesions up to 14 minutes post injection while decreasing in inguinal lymph nodes interpreted as benign. Furthermore, it was very useful in differentiating local recurrences from confounding blood pool and urinary activity.
Pubmed
Web of science
Create date
27/03/2009 9:12
Last modification date
20/08/2019 14:23
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