Association of candidate genes with phenotypic traits relevant to anorexia nervosa.

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Version: author
Serval ID
serval:BIB_68AD1095AC59
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of candidate genes with phenotypic traits relevant to anorexia nervosa.
Journal
European Eating Disorders Review : the Journal of the Eating Disorders Association
Author(s)
Root T.L., Szatkiewicz J.P., Jonassaint C.R., Thornton L.M., Pinheiro A.P., Strober M., Bloss C., Berrettini W., Schork N.J., Kaye W.H., Bergen A.W., Magistretti P., Brandt H., Crawford S., Crow S., Fichter M.M., Goldman D., Halmi K.A., Johnson C., Kaplan A.S., Keel P.K., Klump K.L., La Via M., Mitchell J.E., Rotondo A., Treasure J., Woodside D.B., Bulik C.M.
ISSN
1099-0968 (Electronic)
ISSN-L
1072-4133
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
19
Number
6
Pages
487-493
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.
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Web of science
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28/10/2011 8:27
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20/08/2019 14:23
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