Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_689ECE78C085
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
Journal
Nature communications
Author(s)
Jones S.E., van Hees V.T., Mazzotti D.R., Marques-Vidal P., Sabia S., van der Spek A., Dashti H.S., Engmann J., Kocevska D., Tyrrell J., Beaumont R.N., Hillsdon M., Ruth K.S., Tuke M.A., Yaghootkar H., Sharp S.A., Ji Y., Harrison J.W., Freathy R.M., Murray A., Luik A.I., Amin N., Lane J.M., Saxena R., Rutter M.K., Tiemeier H., Kutalik Z., Kumari M., Frayling T.M., Weedon M.N., Gehrman P.R., Wood A.R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
05/04/2019
Peer-reviewed
Oui
Volume
10
Number
1
Pages
1585
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: epublish
Abstract
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10 <sup>-8</sup> , of which 20 reach a stricter threshold of P < 8 × 10 <sup>-10</sup> . These include 26 novel associations with measures of sleep quality and 10 with nocturnal sleep duration. The majority of identified variants associate with a single sleep trait, except for variants previously associated with restless legs syndrome. For sleep duration we identify a missense variant (p.Tyr727Cys) in PDE11A as the likely causal variant. As a group, sleep quality loci are enriched for serotonin processing genes. Although accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome, these findings provide new biological insights into sleep compared to previous efforts based on self-report sleep measures.
Keywords
Accelerometry/methods, Circadian Rhythm, Humans, Polymorphism, Single Nucleotide, Polysomnography/methods, Serotonin/genetics, Serotonin/metabolism, Sleep/genetics, Sleep Wake Disorders/diagnosis, Sleep Wake Disorders/genetics, Waist-Hip Ratio
Pubmed
Web of science
Open Access
Yes
Create date
22/04/2019 14:09
Last modification date
20/08/2019 14:23
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