Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system

Details

Serval ID
serval:BIB_6890A04F4354
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system
Journal
Semin Cancer Biol
Author(s)
Romao S., Gannage M., Munz C.
ISSN
1096-3650 (Electronic)
ISSN-L
1044-579X
Publication state
Published
Issued date
10/2013
Volume
23
Number
5
Pages
391-6
Language
english
Notes
Romao, Susana
Gannage, Monique
Munz, Christian
eng
R01CA108609/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
England
Semin Cancer Biol. 2013 Oct;23(5):391-6. doi: 10.1016/j.semcancer.2013.03.001. Epub 2013 Mar 27.
Abstract
Macroautophagy was originally discovered as a nutrient salvage pathway during starvation. By now it has not only become clear that degradation of cytoplasmic constituents via transport by autophagosomes to lysosomes can be used for innate and adaptive immunity, but that the core machinery assists antigen presentation to the immune system by a variety of vesicular transport pathways. All of these rely on the presentation of small protein waste fragments, which are generated by a variety of catabolic pathways, including macroautophagy, on major histocompatibility complex (MHC) molecules. In this review, we will point out how classical macroautophagy, as well as phagocytosis and exocytosis, which both benefit from the core autophagic machinery, assist in antigen presentation on MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. Finally to high-light that macroautophagy is always intimately interconnected with cell death in addition to the various supported vesicular transport function, its role in lymphocyte, especially T cell, development and function will be discussed. From this body of work a picture is emerging that the core machinery of macroautophagy can be used for a variety of vesicular transport pathways and to modulate cell survival, besides its classical role in delivering intracellular material for lysosomal degradation.
Keywords
Animals, Antigen Presentation/*immunology, Autophagy/*immunology, Exocytosis/*immunology, Humans, Immune System/*immunology, Phagocytosis/*immunology, CD4(+) T cells, CD8(+) T cells, Exocytosis, MHC class I, MHC class II, Phagocytosis, T cell selection
Pubmed
Create date
10/03/2022 10:43
Last modification date
11/03/2022 6:33
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