Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.

Details

Serval ID
serval:BIB_6888D6D114F4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.
Journal
Journal of Cellular Physiology
Author(s)
Cruise J.L., Cotecchia S., Michalopoulos G.
ISSN
0021-9541 (Print)
ISSN-L
0021-9541
Publication state
Published
Issued date
1986
Volume
127
Number
1
Pages
39-44
Language
english
Abstract
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.
Keywords
Animals, Cells, Cultured, DNA/biosynthesis, Epidermal Growth Factor/metabolism, Female, Liver/cytology, Liver/drug effects, Norepinephrine/pharmacology, Pindolol/pharmacology, Prazosin/pharmacology, Rats, Rats, Inbred F344, Receptor, Epidermal Growth Factor, Receptors, Cell Surface/metabolism, Yohimbine/pharmacology
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 14:23
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