Renal effects of low-dose aminophylline and enprofylline in newborn rabbits.

Details

Serval ID
serval:BIB_6857EAA74493
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Renal effects of low-dose aminophylline and enprofylline in newborn rabbits.
Journal
Life sciences
Author(s)
Gouyon J.B., Arnaud M., Guignard J.P.
ISSN
0024-3205 (Print)
ISSN-L
0024-3205
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
42
Number
13
Pages
1271-1278
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Renal function was studied in 15 newborn New Zealand rabbits administered either 0.6 mg/kg enprofylline intravenously. Each animal acted as its own control. Glomerular filtration rate (GFR) and renal blood flow (RBF) were assessed by the clearances of inulin and para-aminohippuric acid, respectively. Enprofylline, a xanthine with low adenosine antagonistic properties, did not modify urine flow rate, GFR, RBF, renal vascular resistance, filtration fraction, sodium and potassium urinary excretion, whereas administration of theophylline, a potent adenosine antagonist, was associated with a significant increase in diuresis, renal vascular resistance and filtration fraction. The differences observed in the renal effects of theophylline and enprofylline strongly support the view that 1) the renal actions of micromolar concentrations of theophylline are mediated by an antagonism with endogenous renal adenosine; 2) renal adenosine could play a physiological role in the regulation of renal hemodynamics.
Keywords
Aminophylline/pharmacology, Animals, Animals, Newborn/physiology, Diuresis/drug effects, Glomerular Filtration Rate/drug effects, Kidney/blood supply, Kidney/drug effects, Kidney/physiology, Potassium/urine, Rabbits, Renal Circulation/drug effects, Sodium/urine, Vascular Resistance/drug effects, Xanthines/pharmacology
Pubmed
Web of science
Create date
15/08/2018 9:53
Last modification date
20/08/2019 14:23
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