Mitochondrial outer-membrane permeabilization and remodelling in apoptosis.

Details

Serval ID
serval:BIB_684A17508FF7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mitochondrial outer-membrane permeabilization and remodelling in apoptosis.
Journal
The international journal of biochemistry & cell biology
Author(s)
Jourdain Alexis
Publication state
Published
Issued date
09/05/2009
Language
english
Abstract
Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP.
Pubmed
Create date
13/04/2021 17:25
Last modification date
14/04/2021 6:37
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