Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study

Details

Serval ID
serval:BIB_6839EE58A38C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiène
Author(s)
al-Yaman  F., Genton  B., Reeder  J. C., Anders  R. F., Smith  T., Alpers  M. P.
ISSN
0035-9203 (Print)
Publication state
Published
Issued date
10/1997
Volume
91
Number
5
Pages
602-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep-Oct
Abstract
A prospective community study in a highly malaria endemic area of Papua New Guinea found that infection with multiple Plasmodium falciparum genotypes was an indicator of lowered risk of subsequent clinical attack. The results suggest that concurrent or very recent infections provide protection from superinfecting parasites. The finding of an association between reduced risk of clinical malaria and infection with parasites of merozoite surface protein 1 (MSP-1) type RO33 or MSP-2 type 3D7 further suggests that the concomitant immunity is, at least in part, a consequence of a response to these major merozoite surface proteins.
Keywords
Adolescent Age Distribution Animals Child Child, Preschool Cohort Studies Cross-Sectional Studies *Endemic Diseases Genotype Humans Infant Malaria, Falciparum/*epidemiology/parasitology Morbidity Papua New Guinea/epidemiology Plasmodium falciparum/*classification/genetics Polymerase Chain Reaction Prevalence Prospective Studies
Pubmed
Web of science
Create date
28/01/2008 11:49
Last modification date
20/08/2019 14:23
Usage data