Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults.

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Serval ID
serval:BIB_683923592835
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults.
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Author(s)
Santanasto A.J., Glynn N.W., Jubrias S.A., Conley K.E., Boudreau R.M., Amati F., Mackey D.C., Simonsick E.M., Strotmeyer E.S., Coen P.M., Goodpaster B.H., Newman A.B.
ISSN
1758-535X (Electronic)
ISSN-L
1079-5006
Publication state
Published
Issued date
11/2015
Peer-reviewed
Oui
Volume
70
Number
11
Pages
1379-1385
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Fatigability increases while the capacity for mitochondrial energy production tends to decrease significantly with age. Thus, diminished mitochondrial function may contribute to higher levels of fatigability in older adults.
The relationship between fatigability and skeletal muscle mitochondrial function was examined in 30 participants aged 78.5 ± 5.0 years (47% female, 93% white), with a body mass index of 25.9 ± 2.7 kg/m(2) and usual gait-speed of 1.2 ± 0.2 m/s. Fatigability was defined using rating of perceived exertion (6-20 point Borg scale) after a 5-minute treadmill walk at 0.72 m/s. Phosphocreatine recovery in the quadriceps was measured using (31)P magnetic resonance spectroscopy and images of the quadriceps were captured to calculate quadriceps volume. ATPmax (mM ATP/s) and oxidative capacity of the quadriceps (ATPmax·Quadriceps volume) were calculated. Peak aerobic capacity (VO2peak) was measured using a modified Balke protocol.
ATPmax·Quadriceps volume was associated with VO2peak and was 162.61mM ATP·mL/s lower (p = .03) in those with high (rating of perceived exertion ≥10) versus low (rating of perceived exertion ≤9) fatigability. Participants with high fatigability required a significantly higher proportion of VO2peak to walk at 0.72 m/s compared with those with low fatigability (58.7 ± 19.4% vs 44.9 ± 13.2%, p < .05). After adjustment for age and sex, higher ATPmax was associated with lower odds of having high fatigability (odds ratio: 0.34, 95% CI: 0.11-1.01, p = .05).
Lower capacity for oxidative phosphorylation in the quadriceps, perhaps by contributing to lower VO2peak, is associated with higher fatigability in older adults.
Keywords
Adenosine Triphosphate/metabolism, Age Factors, Aged, Aged, 80 and over, Cohort Studies, Energy Metabolism/physiology, Exercise Test, Exercise Tolerance/physiology, Fatigue/etiology, Fatigue/metabolism, Fatigue/physiopathology, Female, Humans, Male, Mitochondria, Muscle/physiology, Quadriceps Muscle/metabolism, Quadriceps Muscle/physiopathology, Walking, Aerobic capacity, Fatigability, Mitochondrial function, Skeletal muscle.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-149398
Swiss National Science Foundation / Careers / PZ00P3-126339
Create date
01/12/2015 17:33
Last modification date
20/01/2020 6:20
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