Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study.

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Serval ID
serval:BIB_6837DD961B3F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study.
Journal
Psychological medicine
Author(s)
Glaus J., von Känel R., Lasserre A.M., Strippoli M.F., Vandeleur C.L., Castelao E., Gholam-Rezaee M., Marangoni C., Wagner E.N., Marques-Vidal P., Waeber G., Vollenweider P., Preisig M., Merikangas K.R.
ISSN
1469-8978 (Electronic)
ISSN-L
0033-2917
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
48
Number
6
Pages
961-973
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hsCRP) with mood disorders.
The sample consisted of 3118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), randomly selected from the general population, who underwent comprehensive somatic and psychiatric evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. Associations were tested by multiple linear and logistic regression models.
Current combined MDD [β = 0.29, 95% confidence interval (CI) 0.03-0.55] and current atypical MDD (β = 0.32, 95% CI 0.10-0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little evidence for inflammation markers at baseline predicting mood disorders at follow-up.
The prospective unidirectional association between current MDD subtype with atypical features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular diseases, warrants further study. Future research that examines potential influences of medications on inflammatory processes is indicated.
Keywords
Adult, Aged, Biomarkers/blood, C-Reactive Protein/analysis, Depressive Disorder, Major/blood, Depressive Disorder, Major/epidemiology, Female, Humans, Inflammation/blood, Interleukin-6/blood, Linear Models, Logistic Models, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Switzerland/epidemiology, Tumor Necrosis Factor-alpha/blood, Atypical depression, C-reactive protein, cardiovascular risk factors, mood disorders, pro-inflammatory cytokines, prospective study
Pubmed
Web of science
Create date
29/09/2017 6:44
Last modification date
27/09/2019 8:49
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