Mouse fibroblasts that express a cloned gene for the human transferrin receptor induce a specific cytolytic T cell response

Details

Serval ID
serval:BIB_68313C2FC7DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mouse fibroblasts that express a cloned gene for the human transferrin receptor induce a specific cytolytic T cell response
Journal
European Journal of Immunology
Author(s)
Maryanski  J. L., Kuhn  L. C., Corradin  G.
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
03/1987
Volume
17
Number
3
Pages
441-3
Notes
Journal Article --- Old month value: Mar
Abstract
From CBA mice immunized with mouse L cells that express a cloned gene for the human transferrin receptor (hTR) we have isolated cytolytic T cells (CTL). The CTL were Lyt-2+/L3T4- and lysed L cell transfectant clones that expressed the hTR gene but not control untransfected L cells or transfectants selected for the expression of an unrelated human cell surface antigen, 4F2. Lysis of independent hTR transfectant clones correlated with the relative level of receptor expression. The availability of CTL directed against a non-major histocompatibility complex-controlled cellular protein-like hTR may provide an interesting model system for studying antigen processing and recognition.
Keywords
Animals Cloning, Molecular Cytotoxicity, Immunologic Humans Immunity, Cellular Mice Receptors, Transferrin/genetics/*immunology Recombinant Proteins/immunology Species Specificity T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Create date
24/01/2008 14:55
Last modification date
20/08/2019 14:23
Usage data