A new vascular sealant (Sealgel) to achieve rapid hemostasis after percutaneous angioplasty in anticoagulated patients: clinical feasibility and preliminary results.

Details

Serval ID
serval:BIB_68201E5EB27D
Type
Article: article from journal or magazin.
Collection
Publications
Title
A new vascular sealant (Sealgel) to achieve rapid hemostasis after percutaneous angioplasty in anticoagulated patients: clinical feasibility and preliminary results.
Journal
European Radiology
Author(s)
Lefebvre J.M., Qanadli S.D., Kacher S., Aberkane L., Rigaud M., Lacombe P., Rocha P.
ISSN
0938-7994
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
11
Number
3
Pages
454-9
Language
english
Notes
Publication types: Journal Article
Abstract
The aim of this study was to assess the feasibility of a new vascular sealant (Sealgel) to provide rapid hemostasis in anticoagulated patients after percutaneous transluminal angioplasty (PTA). Sealgel was designed with ancrod (10 mg) and tranexamic acid (80 mg) dissolved in a hyaluronic acid gel (3 ml). Fifty anticoagulated patients (heparin, aspirin, ticlopidin) who underwent PTA of coronary artery were enrolled in the study. Sealgel (3 ml) was delivered under manual compression through a 9-F cannula at the arterial puncture site after the introducer sheath removal at the end of PTA procedure. Hemostasis time as well as complications were recorded. Sealgel was successfully delivered in 98 % of patients. Hemostasis occurred within 15 mn of manual compression in 82 % of patients, within 25 mn in 98 %, and failed in 1 patient (2 %). Hematoma (6-cm diameter) was observed in 1 patient and late bleeding in another one. There were no clinical signs of embolism, inflammatory swelling, local infection, vascular fistula, or pseudoaneurysm. No surgery or blood transfusion was required. Sealgel application after PTA in anticoagulated patient is feasible and secure. Preliminary results suggest that the Sealgel brought about rapid hemostasis; however further studies are needed to determine its clinical efficacy.
Keywords
Aged, Ancrod/administration & dosage, Angina Pectoris/therapy, Angina, Unstable/therapy, Angioplasty, Transluminal, Percutaneous Coronary, Animals, Anticoagulants/administration & dosage, Anticoagulants/adverse effects, Bandages, Blood Coagulation Tests, Drug Combinations, Feasibility Studies, Female, Femoral Artery/drug effects, Gels, Hemostatic Techniques, Hemostatics/administration & dosage, Humans, Hyaluronic Acid, Male, Middle Aged, Myocardial Infarction/therapy, Punctures, Rabbits, Tranexamic Acid/administration & dosage
Pubmed
Web of science
Create date
09/04/2008 16:12
Last modification date
20/08/2019 14:23
Usage data