Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study.

Details

Serval ID
serval:BIB_6818B67DF1BE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study.
Journal
The British journal of dermatology
Author(s)
Berneburg M., Herzinger T., Rampf J., Hoetzenecker W., Guenova E., Meisner C., Maetzke J., Schaefer T., Eberlein B., Scharffetter-Kochanek K., Rocken M.
ISSN
1365-2133 (Electronic)
ISSN-L
0007-0963
Publication state
Published
Issued date
09/2013
Peer-reviewed
Oui
Volume
169
Number
3
Pages
704-708
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8-methoxypsoralen (8-MOP) can be applied either orally (system PUVA) or topically in a warm water bath (bath PUVA).
To compare bath PUVA and system PUVA in the treatment of plaque psoriasis.
This was a randomized, open, prospective, multicentre trial. We included 74 patients with moderate-to-severe plaque psoriasis during a 6-week treatment and a 4-week follow-up period. Of the patients enrolled in the study, 38 received bath PUVA and 36 system PUVA.
Both treatment modalities significantly reduced the median Psoriasis Area and Severity Index (PASI) score in the intention-to-treat population. Within 6 weeks bath PUVA reduced the median PASI by 74% (16·4 to 4·2) while system PUVA did so by 62% (15·3 to 5·8). The difference between the two modalities was not significant with regard to treatment efficacy (P = 0·389).
There is no difference between bath PUVA and system PUVA in the treatment of psoriasis.
Keywords
Administration, Cutaneous, Administration, Oral, Adult, Aged, Baths, Female, Humans, Male, Methoxsalen/administration & dosage, Middle Aged, PUVA Therapy/methods, Photosensitizing Agents/administration & dosage, Prospective Studies, Psoriasis/drug therapy, Treatment Outcome, Young Adult
Pubmed
Web of science
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
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