Regional brain activity and subjective sleepiness upon awakening: a high-density EEG study

Details

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State: Public
Version: After imprimatur
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Serval ID
serval:BIB_67E1DECFE045
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
Regional brain activity and subjective sleepiness upon awakening: a high-density EEG study
Author(s)
SINGH VIRK A.
Director(s)
SICLARI F.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2020
Language
english
Number of pages
23
Abstract
Why do we sometimes feel sleepy as we wake up? Why is it sometimes harder to get active in the morning? In the present study, we investigated the determinants of subjective sleepiness upon awakening (546 awakenings) in 20 healthy subjects who were recorded with high-density electroencephalography (EEG). Surprisingly, we found that subjective sleepiness was higher upon awakening from REM sleep as compared to NREM sleep, even when adjusting for time spent asleep before the awakening. Sleepiness at awakening correlated with subjective sleep depth before the awakening and was highest when subjects did not report conscious experiences. At the EEG level, we found that awakenings from both REM and NREM sleep were characterized by the persistence of ‘sleep-like’ low-frequency activity (delta and theta power) in posterior brain regions. Furthermore, subjective sleepiness negatively correlated with high-frequency activity and positively with low-frequency activity immediately after awakening. The effect of ‘EEG activation’ was not localized, but rather diffuse. These results challenge the common assumption that subjective sleepiness is strongest upon awakening from ‘deep’ slow wave sleep. They also suggest that the awakening process displays distinctive regional activity patterns, with anterior and central brain regions ‘waking up’ before posterior regions. Finally, these results provide an objective correlate of subjective sleepiness.
Keywords
awakening, sleepiness, high-density EEG, REM sleep, sleep inertia
Create date
07/09/2021 13:12
Last modification date
18/11/2022 6:42
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