Dense granular bodies: a novel nucleoplasmic structure in hibernating dormice.

Details

Serval ID
serval:BIB_67BD454AEA50
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dense granular bodies: a novel nucleoplasmic structure in hibernating dormice.
Journal
Histochemistry and Cell Biology
Author(s)
Tamburini M., Malatesta M., Zancanaro C., Martin T.E., Fu X.D., Vogel P., Fakan S.
ISSN
0948-6143 (Print)
ISSN-L
0948-6143
Publication state
Published
Issued date
1996
Volume
106
Number
6
Pages
581-586
Language
english
Abstract
Dense granular bodies (DGB) are particular structural constituents observed in cell nuclei of different tissues-liver, pancreas, brown adipose tissue, adrenal cortex-of hibernating dormice. They appear as strongly electron-dense clusters of closely packed granules, with thin fibrils spreading out at their periphery. DGB always occur in the nucleoplasm, sometimes making contact with other nuclear structural constituents typical of the hibernating state, such as coiled bodies, amorphous bodies and nucleoplasmic fibrils. DGB are present only during deep hibernation and rapidly disappear upon arousal from hibernation. Cytochemical and immunocytochemical analyses showed that DGB contain ribonucleoproteins and several nucleoplasmic RNA processing factors, suggesting that DGB can represent accumulation sites of splicing factors which are provided to splicing sites when normal metabolic activity is rapidly restored during arousal.
Keywords
Adrenal Glands/cytology, Animals, Arousal, Cell Nucleus/chemistry, Cell Nucleus/ultrastructure, Hibernation/physiology, Immunohistochemistry, Liver/cytology, Microscopy, Electron, Pancreas/cytology, RNA/metabolism, Rodentia/physiology
Pubmed
Web of science
Create date
24/01/2008 17:32
Last modification date
20/08/2019 14:23
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