Pulmonary complications after liver transplantation in children: risk factors and impact on early post-operative morbidity.

Details

Serval ID
serval:BIB_678F3969360A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pulmonary complications after liver transplantation in children: risk factors and impact on early post-operative morbidity.
Journal
Pediatric transplantation
Author(s)
Ruchonnet-Metrailler I. (co-first), Blanchon S. (co-first), Luthold S., Wildhaber B.E., Rimensberger P.C., Barazzone-Argiroffo C., Mc Lin V.A.
ISSN
1399-3046 (Electronic)
ISSN-L
1397-3142
Publication state
Published
Issued date
17/07/2018
Peer-reviewed
Oui
Volume
22
Number
6
Pages
e13243
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Liver transplantation (LT) is associated with high post-operative morbidity, despite excellent survival rates. With this retrospective study, we report the incidence of early and late pulmonary complications (PC) after LT, identify modifiable risk factors for PC and analyzed the role of PC in post-operative ventilation duration and hospital length of stay. In a series of 79 children (0-16 years) with LT over a 12 years period, early (<3 months post-LT) and/or late (>3 months post-LT) PC occurred in 68 patients (86%). Sixty-four percent (64%) developed early major complications such as pulmonary edema, atelectasis, or pleural effusion. Atelectasis requiring an intervention (P ≤ .02), pulmonary edema (P ≤ .02), or elevated PELD/MELD scores (P = .05) were associated with an increase in total ventilation duration and length of stay in the ICU. Risk factors for early PC included preoperative hypoxemia (P = .005), low serum albumin at LT admission (P = .003), or early rejection (P = .002). About 20% of patients experienced late PC of which 81% were infections. Risk factor assessment prior to LT may ultimately help reduce early PC thereby possibly minimizing post-operative morbidity and ICU length of stay.
Keywords
intensive care unit, liver transplantation, pulmonary complications, ventilation
Pubmed
Web of science
Create date
08/10/2018 9:11
Last modification date
16/05/2020 6:22
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