Higher expression of somatic repair genes in long-lived ant queens than workers.

Details

Ressource 1Download: a346ME2GwppZsmhPg.pdf (389.50 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_6782ADAC14AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Higher expression of somatic repair genes in long-lived ant queens than workers.
Journal
Aging
Author(s)
Lucas E.R., Privman E., Keller L.
ISSN
1945-4589 (Electronic)
ISSN-L
1945-4589
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
8
Number
9
Pages
1940-1951
Language
english
Abstract
Understanding why organisms senesce is a fundamental question in biology. One common explanation is that senescence results from an increase in macromolecular damage with age. The tremendous variation in lifespan between genetically identical queen and worker ants, ranging over an order of magnitude, provides a unique system to study how investment into processes of somatic maintenance and macromolecular repair influence lifespan. Here we use RNAseq to compare patterns of expression of genes involved in DNA and protein repair of age-matched queens and workers. There was no difference between queens and workers in 1-day-old individuals, but the level of expression of these genes increased with age and this up-regulation was greater in queens than in workers, resulting in significantly queen-biased expression in 2-month-old individuals in both legs and brains. Overall, these differences are consistent with the hypothesis that higher longevity is associated with increased investment into somatic repair.

Keywords
ageing, lifespan, somatic maintenance, social insects, gene expression
Pubmed
Web of science
Create date
23/09/2016 18:21
Last modification date
20/08/2019 14:23
Usage data